Detail Cantuman

a b s t r a c t
Diseases of macrophages are rare entities characterized by the accumulation of macrophages,
dendritic cells or monocyte-derived cells in various tissues and organs. This
article focuses on macrophage disorders which can be present in adult patients. The
review highlights pathogenesis, signs and symptoms, diagnostic criteria and principles of
therapy in the most frequent macrophage diseases in adults: hemophagocytic lymphohistiocytosis,
Rosai-Dorfman disease, Gaucher disease, Niemann-Pick disease, and Langerhans
cell histiocytosis. Since macrophage disorders can be encountered by various
medical specialists, basic knowledge of these entities and their diagnostic criteria should
be familiar to all physicians, including hematologists.
© 2016 Polskie Towarzystwo Hematologów i Transfuzjologów, Instytut Hematologii i